Canine atopic dermatitis (CAD) is a frequent chronic inflammatory skin disease with a well-defined predilection distribution pattern. While immunological and environmental factors are known contributors, growing evidence suggests that the structural properties of the skin barrier itself may play a key role in regional disease expression. However, detailed quantitative reference data on normal canine skin morphology remain limited.
This project aims to establish a comprehensive baseline of healthy canine skin and to examine associations between region-dependent skin characteristics and CAD prevalence. Skin biopsies from clinically healthy dogs have been collected from seven anatomical regions of interest. Using histological morphometric analyses, the study quantifies epidermal thickness, epidermal stratification, dermo-epidermal interface morphology, and dermal vascularization.
We hypothesize that anatomical regions with a high prevalence of CAD display distinct structural features compared to low-prevalence areas, and that these differences may predispose certain sites to impaired barrier function and inflammatory responses.